碧云天生物技术-MG-132 (Proteasome抑制剂)(S1748-5mg)

试剂> 抑制剂激活剂等> 蛋白翻译、折叠和降解> Ubiquitin/Proteasome

MG-132 (Proteasome抑制剂)

一键复制产品信息

产品编号: S1748-5mg

产品包装:5mg

选择包装

20mg/ml×0.05ml 5mg 25mg

数

量

说明书下载

价格: ¥ 415.00

加入购物车

				产品简介
			
				使用说明
			
				产品文件
			
				相关产品
			
				相关论文
			
				产品问答

产品编号	产品名称	产品包装	产品价格
S1748-1mg	MG-132 (Proteasome抑制剂)	20mg/ml×0.05ml	325.00元
S1748-5mg	MG-132 (Proteasome抑制剂)	5mg	415.00元
S1748-25mg	MG-132 (Proteasome抑制剂)	25mg	1461.00元

MG-132也写作MG132，也称Z-LLL-CHO，Z-Leu-Leu-Leu-CHO，Z-Leu-Leu-Leu-al或Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal，是一种常用的Proteasome抑制剂，即蛋白酶体抑制剂。MG-132可以通透细胞，选择性抑制Proteasome，Ki＝4nM。可以激活JNK1并抑制NF-κB的激活(IC50=3μM)。在10μM时可以诱导PC12细胞产生neurite outgrowth。
MG-132分子量为475.62，分子式为C₂₆H₄₁N₃O₅，CAS Number：133407-82-6。本产品纯度大于99%。
本MG-132为进口分装，其中20mg/ml包装产品用DMSO配制，共0.05ml。5mg和25mg包装为粉末装。
包装清单：

产品编号	产品名称	包装
S1748-1mg	MG-132 (Proteasome抑制剂)	20mg/ml×0.05ml
S1748-5mg	MG-132 (Proteasome抑制剂)	5mg
S1748-25mg	MG-132 (Proteasome抑制剂)	25mg
—	说明书	1份

保存条件：
-20℃避光保存，半年有效。
注意事项：
本MG-132在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内，可以20-25℃水浴温育片刻至全部融解后使用。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。

使用说明：

1. MG-132常见使用浓度范围为1-50μM。具体的最佳工作浓度请参考相关文献，或根据实验目的，以及所培养的特定细胞和组织，通过实验进行摸索和优化。

物质安全数据单

输入右侧验证码点击下载：

下载

质检证书

输入批号搜寻COA

搜索

相关产品请点击如下按钮：

Ubiquitin/Proteasome

蛋白修饰酶抑制剂

NF-κB Signaling

使用本产品的文献：

1. Jia Xiong, Jia He, Jun Zhu, Jiongli Pan, Weijie Liao, Hongying Ye, Haofei Wang, Yinjing Song, Yue Du, Bijun Cui, Maoguang Xue, Wanling Zheng, Xiangxing Kong, Kai Jiang, Kefeng Ding, Lihua Lai, Qingqing Wang

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

Mol Cell. 2022 May 5;82(9):1660-1677.e10. doi: 10.1016/j.molcel.2022.02.033. (IF 15.584)

2. Yan Y, Wang H, Hu M, Jiang L, Wang Y, Liu P, Liang X, Liu J, Li C, Lindström-Battle A, Lam SM, Shui G, Deng WM, Jiao R.

HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila.

Dev Cell. 2017 Oct 9;43(1):99-111.e5. (IF 10.092)

3. Min Dong, Min Qian, Zhengyi Ruan

CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein

J Immunother Cancer. 2022 Oct;10(10):e005270. doi: 10.1136/jitc-2022-005270. (IF 9.913)

4. Wang L, Chen M, Yang J, Zhang Z.

LC3 fluorescent puncta in autophagosomes or in protein aggregates can be distinguished by FRAP analysis inliving cells.

Autophagy. 2013 May;9(5):756-69. (IF 9.77)

5. Tingjuan Deng, Boli Hu, Xingbo Wang, Shuxiang Ding, Lulu Lin, Yan Yan, Xiran Peng, Xiaojuan Zheng, Min Liao, Yulan Jin, Weiren Dong, Jinyan Gu, Jiyong Zhou

TRAF6 autophagic degradation by avibirnavirus VP3 inhibits antiviral innate immunity via blocking NFKB/NF-κB activation

Autophagy. 2022 Dec;18(12):2781-2798. doi: 10.1080/15548627.2022.2047384. (IF 9.77)

6. Liang Y, Hu J, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X, Hong D, Yang Q, Hu G.

Epigenetic Activation of TWIST1 by MTDH Promotes Cancer Stem-like Cell Traits in Breast Cancer.

Cancer Res. 2015 Sep 1;75(17):3672-80. (IF 9.727)

7. Jiang J, Xu Y, Ren H, Wudu M, Wang Q, Song X, Su H, Jiang X, Jiang L, Qiu X

MKRN2 inhibits migration and invasion of non-small-cell lung cancer by negatively regulating the PI3K/Akt pathway.

J EXP CLIN CANC RES. 2018 Aug 13;37(1):189. (IF 7.068)

8. Li C, Du L, Ren Y, Liu X, Jiao Q, Cui D, Wen M, Wang C, Wei G, Wang Y, Ji A, Wang Q

SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination.

J EXP CLIN CANC RES. 2019 Feb 13 38(1):76. (IF 7.068)

9. Wei Wu, Yang Qu, Shengqing Yu, Sa Wang, Yuncong Yin, Qinfang Liu, Chunchun Meng, Ying Liao, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding, Yingjie Sun

Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity

mBio. 2021 Jun 29;12(3):e0100521. doi: 10.1128/mBio.01005-21. (IF 6.784)

10. Zhenguang Ying, Kaifang Wang, Junfeng Wu, Mingyu Wang, Jing Yang, Xia Wang, Guowei Zhou, Haibin Chen, Hongwu Xu, Stephen Cho Wing Sze, Feng Gao, Chunman Li, Ou Sha

CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72

BMC Biol. 2022 Oct 24;20(1):240. doi: 10.1186/s12915-022-01437-6. (IF 6.765)

11. Chen X, Cao X, Sun X, Lei R, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, Hou Y, Wang M, Siebenlist U, Eugene Chin Y, Wang Y, Cao L, Hu G, Zhang X.

Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis.

Cell Death Dis. 2016 Dec 1;7(12):e2508. (IF 6.304)

12. Li Y, Qin Y, Yang C, Zhang H, Li Y, Wu B, Huang J, Zhou X, Huang B, Yang K, Wu G.

Cardamonin induces ROS-mediated G2/M phase arrest and apoptosis through inhibition of NF-κB pathway in nasopharyngeal carcinoma.

Cell Death Dis. 2017 Aug 31;8(8):e3024. (IF 6.304)

13. Mengling Zhang, Hongmei Qiu, Lejiao Mao, Bin Wang, Na Li, Yinzhen Fan, Ping Weng, Siyao Hu, Xiaomei Dong, Xia Qin, Chengzhi Chen, Zhen Zou, Chao Yu, Jun Zhang

Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells

Cell Death Dis. 2022 Aug 25;13(8):733. doi: 10.1038/s41419-022-05183-z. (IF 6.304)

14. Jiacheng Lin, Limin Yin, Xia-Zhen Xu, He-Chen Sun, Zhi-Hua Huang, Xue-Yun Ni, Yan Chen, Xu Lin

Bay41-4109-induced aberrant polymers of hepatitis b capsid proteins are removed via STUB1-promoted p62-mediated macroautophagy

PLoS Pathog. 2022 Jan 14;18(1):e1010204. doi: 10.1371/journal.ppat.1010204. (IF 6.218)

15. Chen L, Mai W, Chen M, Hu J, Zhuo Z, Lei X, Deng L, Liu J, Yao N, Huang M, Peng Y, Ye W, Zhang D.

Arenobufagin inhibits prostate cancer epithelial-mesenchymal transition and metastasis by down-regulating β-catenin.

Pharmacol Res. 2017 Sep;123:130-142. (IF 5.893)

16. Chen H, Zhang Y, Ye S, Wu Q, Lin Y, Sheng K, Chen W, Lin X, Lin X

Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation.

EMERG MICROBES INFEC. 2019 8(1):1393-1405. (IF 5.776)

17. Huang HL, Weng HY, Wang LQ, Yu CH, Huang QJ, Zhao PP, Wen JZ, Zhou H, Qu LH.

Triggering Fbw7-mediated proteasomal degradation of c-Myc by oridonin induces cell growthinhibition and apoptosis.

Mol Cancer Ther. 2012 May;11(5):1155-65. (IF 5.615)

18. Zhu C, Zhu Q, Wu Z, Yin Y, Kang D, Lu S, Liu P.

Isorhapontigenin induced cell growth inhibition and apoptosis by targeting EGFR-relatedpathways in prostate cancer.

J Cell Physiol. 2018 Feb;233(2):1104-1119. (IF 5.546)

19. Zhang C, Yang L, Geng YD, An FL, Xia YZ, Guo C, Luo JG, Zhang LY, Guo QL, Kong LY.

Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells.

ONCOTARGET. 2016 May 10;7(19):27819-37. (IF 5.168)

20. Zhang X, Jiang G, Sun M, Zhou H, Miao Y, Liang M, Wang E, Zhang Y.

Cytosolic THUMPD1 promotes breast cancer cells invasion and metastasis via the AKT-GSK3-Snail pathway.

ONCOTARGET. 2017 Feb 21;8(8):13357-13366. (IF 5.168)

21. Ren H, Xu Y, Wang Q, Jiang J, Wudumuli, Hui L, Zhang Q, Zhang X, Wang E, Sun L, Qiu X

E3 ubiquitin ligase tripartite motif-containing 71 promotes the proliferation of non-small cell lung cancer through the inhibitor of kappaB-α/nuclear factor kappaB pathway.

ONCOTARGET. 2017 Jul 7;9(13):10880-10890. (IF 5.168)

22. Wu H, Chen Y, Wang ZY, Li W, Li JQ, Zhang L, Lu YJ.

Neuroscience. 2010;170(1):149-55. (IF 3.056)

23. Wu H, Chen Y, Wang ZY, Li W, Li JQ, Zhang L, Lu YJ.

Involvement of p21 (waf1) in merlin deficient sporadic vestibular schwannomas.

Neuroscience. 2010;170(1):149-55. (IF 3.056)

24. Wen L, Liu J, Chen Y, Wu D.

Identification and preliminary functional analysis of alternative splicing of Siah1 in Xenopus laevis.

BIOCHEM BIOPH RES CO. 2010;396(2):419-24. (IF 2.985)

25. Li L, Cui D, Zheng SJ, Lou H, Tang J.

Regulation of Actinomycin D induced upregulation of Mdm2 in H1299 cells.

DNA REPAIR. 2012 Feb 1;11(2):112-9. (IF 3.339)

26. Lu L, Song HF, Zhang WG, Liu XQ, Zhu Q, Cheng XL, Yang GJ, Li A, Xiao ZC.

Potential role of 20S proteasome in maintaining stem cell integrity of human bone marrow stromalcells in prolonged culture expansion.

BIOCHEM BIOPH RES CO. 2012 May 25;422(1):121-7. (IF 2.985)

27. Wang D, Fang L, Li K, Zhong H, Fan J, Ouyang C, Zhang H, Duan E, Luo R, Zhang Z, Liu X, Chen H, Xiao S.

Foot-and-Mouth Disease Virus 3C Protease Cleaves NEMO To Impair Innate Immune Signaling.

J Virol. 2012 Sep;86(17):9311-22. (IF 4.501)

28. Qiu M, Chen Y, Chu Y, Song S, Yang N, Gao J, Wu Z.

Zinc ionophores pyrithione inhibits herpes simplex virus replication through interfering with proteasome functionand NF-κB activation.

ANTIVIR RES. 2013 Oct;100(1):44-53. (IF 4.101)

29. Zhou Y, Chen S, Ding R, Yao W, Gao X.

Inflammatory modulation effect of glycopeptide from Ganoderma capense (Lloyd) Teng.

MEDIAT INFLAMM. 2014;2014:691285. (IF 3.758)

30. Chen HY, Ren XY, Wang WH, Zhang YX, Chen SF, Zhang B, Wang LX.

Upregulated ROS production induced by the proteasome inhibitor MG-132 on XBP1 gene expression and cell apoptosis in Tca-8113 cells.

Biomed Pharmacother. 2014 Jul;68(6):709-13. (IF 4.545)

31. Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H.

PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.

J Biol Chem. 2014 Oct 24;289(43):29739-49. (IF 4.238)

32. Dong QM, Ling C, Zhu JF, Chen X, Tang Y, Zhao LI.

Correlation between p65 and TNF-α in patients with acute myelocytic leukemia.

Oncol Lett. 2015 Nov;10(5):3305-9. (IF 2.311)

33. Xu Y, Liu F, Liu J, Wang D, Yan Y, Ji S, Zan J, Zhou J.

The co-chaperone Cdc37 regulates the rabies virus phosphoprotein stability by targeting to Hsp90AA1machinery.

SCI REP-UK. 2016 Jun 2;6:27123. (IF 3.998)

34. Qiu P, Wang S, Liu M, Ma H, Zeng X, Zhang M, Xu L, Cui Y, Xu H, Tang Y, He Y, Zhang L.

Norcantharidin Inhibits cell growth by suppressing the expression and phosphorylation of both EGFR and c-Met in human colon cancer cells.

BMC Cancer. 2017 Jan 13;17(1):55. (IF 3.15)

35. Li XH, Xue WL, Wang MJ, Zhou Y, Zhang CC, Sun C, Zhu L, Liang K, Chen Y, Tao BB, Tan B, Yu B, Zhu YC.

H2S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3pexpression.

SCI REP-UK. 2017 Mar 21;7:44807. (IF 3.998)

36. Su AR, Qiu M, Li YL, Xu WT, Song SW, Wang XH, Song HY, Zheng N, Wu ZW.

BX-795 inhibits HSV-1 and HSV-2 replication by blocking the JNK/p38 pathways without interfering with PDK1 activity in host cells.

Acta Pharmacol Sin. 2017 Mar;38(3):402-414. (IF 5.064)

37. Zhu X, Wang D, Zhou J, Pan T, Chen J, Yang Y, Lv M, Ye X, Peng G, Fang L, Xiao S.

Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2.

J Virol. 2017 Apr 28;91(10). pii: e00003-17. (IF 4.501)

38. Ren H, Xu Y, Wang Q, Jiang J, Wudumuli, Hui L, Zhang Q, Zhang X, Wang E, Sun L, Qiu X.

E3 ubiquitin ligase tripartite motif-containing 71 promotes the proliferation of non-small cell lungcancer throughthe inhibitor ofkappaB-α/nuclear factor kappaB pathway.

ONCOTARGET. 2017 Jul 7;9(13):10880-10890. (IF 5.168)

39. Li H, Al-Japairai K, Tao Y, Xiang Z.

RPN2 promotes colorectal cancer cell proliferation through modulating the glycosylation status of EGFR.

ONCOTARGET. 2017 Aug 7;8(42):72633-72651. (IF 5.168)

40. Ke W, Fang L, Jing H, Tao R, Wang T, Li Y, Long S, Wang D, Xiao S.

Cholesterol 25-Hydroxylase Inhibits Porcine Reproductive and Respiratory Syndrome VirusReplication through Enzyme Activity-Dependent and -Independent Mechanisms.

J Virol. 2017 Sep 12;91(19). pii: e00827-17. (IF 4.501)

41. Xia J, Kong L, Zhou LJ, Wu SZ, Yao LJ, He C, He CY, Peng HJ.

Genome-Wide Bimolecular Fluorescence Complementation-Based Proteomic Analysis of Toxoplasma gondii ROP18's Human Interactome Shows Its Key Role in Regulation of Cell Immunity and Apoptosis.

Front Immunol. 2018 Feb 5;9:61. (IF 5.085)

42. Lin C, Gu J, Wang H, Zhou J, Li J, Wang S, Jin Y, Liu C, Liu J, Yang H, Jiang P, Zhou J.

Caspase-dependent apoptosis induction via viral protein ORF4 of porcine circovirus 2 binding to mitochondrial adenine nucleotide translocase 3.

J Virol. 2018 Feb 28. pii: JVI.00238-18. (IF 4.501)

43. Wang LC, Wei WH, Zhang XW, Liu D, Zeng KW, Tu PF

An Integrated Proteomics and Bioinformatics Approach Reveals the Anti-inflammatory Mechanism of Carnosic Acid.

Front Pharmacol. 2018 Apr 16;9:370. (IF 4.225)

44. Ye X, Pan T, Wang D, Fang L, Ma J, Zhu X, Shi Y, Zhang K, Zheng H, Chen H, Li K, Xiao S

Foot-and-Mouth Disease Virus Counteracts on Internal Ribosome Entry Site Suppression by G3BP1 and Inhibits G3BP1-Mediated Stress Granule Assembly via Post-Translational Mechanisms.

Front Immunol. 2018 May 25;9:1142. (IF 5.085)

45. Zheng K, Liu Q, Wang S, Ren Z, Kitazato K, Yang D, Wang Y

HSV-1-encoded microRNA miR-H1 targets Ubr1 to promote accumulation of neurodegeneration-associated protein.

Virus Genes. 2018 Jun;54(3):343-350. (IF 1.991)

46. Zhang Q, Zhang P, Qi GJ, Zhang Z, He F, Lv ZX, Peng X, Cai HW, Li TX, Wang XM, Tian B

Cdk5 suppression blocks SIRT1 degradation via the ubiquitin-proteasome pathway in Parkinson's disease models.

BBA-GEN SUBJECTS. 2018 Jun;1862(6):1443-1451. (IF 3.422)

47. Song T, Su H, Yin W, Wang L, Huang R

Acetylation modulates LC3 stability and cargo recognition.

FEBS Lett. 2019 Feb 593(4):414-422. (IF 3.057)

48. Wei Y, Huang C, Wu H, Huang J

Estrogen Receptor Beta (ERβ) Mediated-CyclinD1 Degradation via Autophagy Plays an Anti-Proliferation Role in Colon Cells.

Int J Biol Sci. 2019 Mar 10 15(5):942-952. (IF 4.858)

49. Duan W, Guo M, Yi L, Zhang J, Bi Y, Liu Y, Li Y, Li Z, Ma Y, Zhang G, Liu Y, Song X, Li C

Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice.

AGING-US. 2019 Apr 30 11(8):2457-2476. (IF 4.831)

50. Cai L, Li J, Zhao J, Guo Y, Xie M, Zhang X, Wang L, Tian H, Li A, Li Q, Miao Y

Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer.

FEBS Lett. 2019 Jul 593(14):1827-1836. (IF 3.057)

51. Li R, Liu Y, Shan YG, Gao L, Wang F, Qiu CG

Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effects.

Oxid Med Cell Longev. 2019 Jul 1 2019:3206542. (IF 5.076)

52. Wang W, Wei R, Liu S, Qiao L, Hou J, Gu C, Yang Y

BTK induces CAM-DR through regulation of CXCR4 degradation in multiple myeloma.

Am J Transl Res. 2019 Jul 15 11(7):4139-4150. eCollection 2019. (IF 3.375)

53. Luca M, Di Mauro M, Perry G

Neuropsychiatric Disturbances and Diabetes Mellitus: The Role of Oxidative Stress.

Oxid Med Cell Longev. 2019 Jul 4 2019:5698132. (IF 5.076)

54. Yanmei Zhang, Sauhar Lee, Wei Xu

Miltefosine suppression of Pten null T-ALL leukemia via β-catenin degradation through inhibition of pT308-Akt and TGFβ1/Smad3

Biochem Biophys Res Commun. 2020 Apr 16;524(4):1018-1024. doi: 10.1016/j.bbrc.2020.02.021.

55. Lin Lv, Mingzhu Cao, Juan Bai, Ling Jin, Xianwei Wang, Yanni Gao, Xuewei Liu, Ping Jiang

PRV-encoded UL13 protein kinase acts as an antagonist of innate immunity by targeting IRF3-signaling pathways

Vet Microbiol. 2020 Nov;250:108860. doi: 10.1016/j.vetmic.2020.108860. (IF 3.03)

56. Maochao Luo, Zhao Huang, Xingyue Yang, Yan Chen, Jingwen Jiang, Lu Zhang, Li Zhou, Siyuan Qin, Ping Jin, Shuyue Fu, Liyuan Peng, Bowen Li, Yongting Fang, Wenchen Pu, Yanqiu Gong, Yu Liu, Zhixiang Ren, Qiu-Luo Liu, Cun Wang, Fangqiong Xiao, Du He, Hongying Zhang, Changlong Li, Heng Xu, Lunzhi Dai, Yong Peng, Zong-Gung Zhou, Canhua Huang, Hai-Ning Chen

PHLDB2 Mediates Cetuximab Resistance via Interacting With EGFR in Latent Metastasis of Colorectal Cancer

Cell Mol Gastroenterol Hepatol. 2022;13(4):1223-1242. doi: 10.1016/j.jcmgh.2021.12.011.

57. Jing Chen, Hongbo Wu, Xudong Tang, Lei Chen

4-Phenylbutyrate protects against rifampin-induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stress

Bioengineered. 2022 Feb;13(2):2866-2877. doi: 10.1080/21655979.2021.2024970. (IF 2.205)

58. Na Li, Hang Du, Lejiao Mao, Ge Xu, Mengling Zhang, Yinzhen Fan, Xiaomei Dong, Lijun Zheng, Bin Wang, Xia Qin, Xuejun Jiang, Chengzhi Chen, Zhen Zou, Jun Zhang

Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles

J Nanobiotechnology. 2022 Jun 11;20(1):270. doi: 10.1186/s12951-022-01486-7.

59. Mengge Yin, Wei Wen, Haoyuan Wang, Qiongqiong Zhao, Hechao Zhu, Huanchun Chen, Xiangmin Li, Ping Qian

Porcine Sapelovirus 3Cpro Inhibits the Production of Type I Interferon

Front Cell Infect Microbiol. 2022 Jun 15:12:852473. doi: 10.3389/fcimb.2022.852473.

60. Xiaoliang Liu, Lu Zhang, Hebo Zhang, Xiaoyan Liang, Bijun Zhang, Jianqiao Tu, Yanyan Zhao

Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures

Front Mol Neurosci. 2022 Jun 27:15:919718. doi: 10.3389/fnmol.2022.919718. (IF 4.057)

61. Wei Chen, Yushan Liu, Shaohong Kang, Xinying Lv, Wenfen Fu, Jie Zhang, Chuangui Song

LINC00092 Modulates Oxidative Stress and Glycolysis of Breast Cancer Cells via Pyruvate Carboxylase-Mediated AKT/mTOR Pathway

Oxid Med Cell Longev. 2022 Jun 28:2022:5215748. doi: 10.1155/2022/5215748. (IF 5.076)

62. Yong Xiang, Yun Yu, Qingbo Li, Jian Chen, Yu Li, Weisheng Cao

Chicken telomerase reverse transcriptase mediates LMH cell pyroptosis by regulating the nuclear factor-kappa B signaling pathway

Poult Sci. 2022 Jun;101(6):101826. doi: 10.1016/j.psj.2022.101826.

63. Xiangrong Li, Jingying Xie, Dianyu Li, Hongshan Li, Yuhui Niu, Bei Wu, Yanmei Yang, Zhenfang Yan, Xiangbo Zhang, Lei Chen, Ruofei Feng

HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection

Viruses. 2022 Aug 23;14(9):1851. doi: 10.3390/v14091851.

64. Shaoqin Zheng, Jiahui Lin, Zhongqiu Pang, Hui Zhang, Yinuo Wang, Lanjing Ma, Haijiao Zhang, Xi Zhang, Maorong Chen, Xinjun Zhang, Chao Zhao, Jun Qi, Liu Cao, Min Wang, Xi He, Ren Sheng

Aberrant Cholesterol Metabolism and Wnt/β-Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth

Adv Sci (Weinh). 2022 Oct;9(28):e2200750. doi: 10.1002/advs.202200750.

65. Xin Peng, Xiaoli Liu, Wanshan Hu, Yanling Zhou, Lianlian Ouyang, Xintong Peng, Yao Long, Jingyue Sun, Tania Tao, Ling Chen, Ying Shi, Yongguang Tao, Desheng Xiao, Shuang Liu

HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1

Cell Death Dis. 2023 Feb 23;14(2):153. doi: 10.1038/s41419-023-05673-8.

66. Deji Ye, Hanshao Liu, Guojun Zhao, Aijun Chen, Yuhang Jiang, Yiming Hu, Dandan Liu, Ningxia Xie, Weifei Liang, Xi Chen, Haohao Zhang, Cuifeng Li, Jingyao Wang, Donglin Sun, Weifeng Chen, Dan Tan, Qi Wang, Hongru Wang, Dianping Yu, Baojin Wu, Mingliang Wang, Shuzhong Cui, Sanhong Liu, Xiaoren Zhang

LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis

Cell Death Dis. 2023 Feb 27;14(2):165. doi: 10.1038/s41419-023-05700-8.

67. Zhan-Cheng Zeng, Qi Pan, Yu-Meng Sun, Heng-Jing Huang, Xiao-Tong Chen, Tian-Qi Chen, Bo He, Hua Ye, Shun-Xin Zhu, Ke-Jia Pu, Ke Fang, Wei Huang, Yue-Qin Chen, Wen-Tao Wang

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis

EMBO Rep. 2023 Mar 6;24(3):e55762. doi: 10.15252/embr.202255762.

68. Yufeng Sun, Lili He, Peiran Guo, Fenghua Li, Bo Wang, Yifan Zhang, Kai An, Ming Peng

F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway

Open Med (Wars). 2023 Apr 17;18(1):20230634. doi: 10.1515/med-2023-0634.

69. Gang Lin, Hao Qi, Xudong Guo, Wenqiang Wang, Minghui Zhang, Xuejun Gao

ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells

J Nutr Biochem. 2023 Apr:114:109274. doi: 10.1016/j.jnutbio.2023.109274.

70. Jian Cheng, Guizhong Zhang, Tian Deng, Zhao Liu, Mengqi Zhang, Pengchao Zhang, Funmilayo O Adeshakin, Xiangyun Niu, Dehong Yan, Xiaochun Wan, Guang Yu

CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation

Cell Death Dis. 2023 May 20;14(5):333. doi: 10.1038/s41419-023-05858-1.

71. Ya-Yun Chen, Xiang-Hong Ran, Run-Ze Ni, Dan Mu

TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination

J Biol Chem. 2023 May;299(5):104660. doi: 10.1016/j.jbc.2023.104660.

72. Lulu Lin, Xingbo Wang, Zhen Chen, Tingjuan Deng, Yan Yan, Weiren Dong, Yu Huang, Jiyong Zhou

TRIM21 restricts influenza A virus replication by ubiquitination-dependent degradation of M1

PLoS Pathog. 2023 Jun 21;19(6):e1011472. doi: 10.1371/journal.ppat.1011472.

73. Zhiying Cui, Likun Zhou, Shijie Zhao, Wen Li, Jiahui Li, Jing Chen, Yina Zhang, Pingan Xia

The Host E3-Ubiquitin Ligase TRIM28 Impedes Viral Protein GP4 Ubiquitination and Promotes PRRSV Replication

Int J Mol Sci. 2023 Jun 30;24(13):10965. doi: 10.3390/ijms241310965.

74. Ben Wang, Jin Zhang, Guo Li, Chenzhong Xu, Langmei Yang, Jie Zhang, Yalan Wu, Ye Liu, Zuojun Liu, Ming Wang, Ji Li, Xiaolong Tang, Baohua Liu