化学信息：
|
化学名
|
(Z)-N-[(2S,3R,4R,5R,6R)-2-[(2S,3S,4S,5R,6S)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan-3-yl]-12-methyltridec-2-enamide
|
|
|
简称
|
Tunicamycin
|
|
别名
|
Tunicamycin from Streptomyces sp.; 链病毒菌素
|
|
中文名
|
衣霉素
|
|
化学式
|
C39H64N4O16
|
|
分子量
|
844.95
|
|
CAS号
|
11089-65-9
|
|
纯度
|
≥98%
|
|
溶剂/溶解度
|
Water <1mg/ml; DMSO 200mg/ml; Ethanol 5mg/ml
|
|
溶液配制
|
5mg加入0.59ml DMSO，或者每8.45mg加入1ml DMSO，配制成10mM溶液。SC0393-10mM用DMSO配制。
|
生物信息：
|
产品描述
|
Tunicamycin is a mixture of Tunicamycins A, B, C and D which has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GNPTAB (GlcNAc phosphotransferase, GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein synthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, to inhibit protein glycosylation, to suppress the S-phase of the cell cycle, and to arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, this compound is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.
|
|
信号通路
|
Translational Control
|
|
靶点
|
－
|
－
|
－
|
－
|
－
|
|
IC50
|
－
|
－
|
－
|
－
|
－
|
|
体外研究
|
N/A
|
|
体内研究
|
N/A
|
|
临床实验
|
N/A
|
|
特征
|
N/A
|
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
|
酶活性检测实验
|
|
方法
|
N/A
|
|
细胞实验
|
|
细胞系
|
N/A
|
|
浓度
|
N/A
|
|
处理时间
|
N/A
|
|
方法
|
N/A
|
|
动物实验
|
|
动物模型
|
N/A
|
|
配制
|
N/A
|
|
剂量
|
N/A
|
|
给药方式
|
N/A
|
参考文献：
Duksin, D., et al. J. Biol. Chem. 1982, 257, 3105-3109.
Langan, T.J. and Slater, M.C. J. Cell Physiol. 1991, 149, 284-292.
Ishii, S. and Volpe, J.J. J. Neurochem. 1987, 49, 1606-1612.
包装清单：
|
产品编号
|
产品名称
|
包装
|
|
SC0393-10mM
|
Tunicamycin (N-连接的糖基化抑制剂)
|
10mM×0.2ml
|
|
SC0393-5mg
|
Tunicamycin (N-连接的糖基化抑制剂)
|
5mg
|
|
—
|
说明书
|
1份
|
保存条件：
-20℃保存，至少一年有效。5mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：
本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
微信在线咨询
微信在线咨询
