产品编号 | 产品名称 | 产品包装 | 产品价格 |
SD2429-10mM | AM630 (CB2拮抗剂) | 10mM×0.2ml | 140.00元 |
SD2429-5mg | AM630 (CB2拮抗剂) | 5mg | 462.00元 |
SD2429-25mg | AM630 (CB2拮抗剂) | 25mg | 1806.00元 |
化学信息:
化学名 | [6-iodo-2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]-(4-methoxyphenyl)methanone |
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简称 | AM630 | |
别名 |
AM 630, AM-630 |
|
中文名 | N/A | |
化学式 | C23H25IN2O3 | |
分子量 | 504.36 | |
CAS号 | 164178-33-0 | |
纯度 | 98% | |
溶剂/溶解度 |
Water<1mg/ml; DMSO5mg/ml; Ethanol<1mg/ml |
|
溶液配制 | 5mg加入0.99ml DMSO,或者每5.04mg加入1ml DMSO,配制成10mM溶液。SD2429-10mM用DMSO配制。 |
生物信息:
产品描述 | AM630 is a selectivity CB2 antagonist with Ki of 31.2nM; >150 fold selectivity over CB1 receptor. | ||||
信号通路 | GPCR & G Protein | ||||
靶点 | CB2 receptor | - | - | - | - |
IC50 | 31.2nM | - | - | - | - |
体外研究 | AM630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2μM and 31.2nM, respectively. AM630 has been shown to display 165-fold selectivity over CB1 receptors and behave as a weak partial/inverse agonist at CB1 receptors. AM630 acts as a cannabinoid receptor antagonist in mouse brain, vas deferens and guinea pig brain, but acts as an agonist in guinea pig leum. AM630 acts as an inverse agonist on cloned human CB1 receptors. | ||||
体内研究 | N/A | ||||
临床实验 | N/A | ||||
特征 | N/A |
相关实验数据(此数据来自于公开文献,碧云天并不保证其有效性):
酶活性检测实验 | |
方法 | N/A |
细胞实验 | |
细胞系 | N/A |
浓度 | N/A |
处理时间 | N/A |
方法 | N/A |
动物实验 | |
动物模型 | N/A |
配制 | N/A |
剂量 | N/A |
给药方式 | N/A |
产品编号 | 产品名称 | 包装 |
SD2429-10mM | AM630 (CB2拮抗剂) | 10mM×0.2ml |
SD2429-5mg | AM630 (CB2拮抗剂) | 5mg |
SD2429-25mg | AM630 (CB2拮抗剂) | 25mg |
— | 说明书 | 1份 |
保存条件:
-20℃保存,至少一年有效。5mg和25mg包装也可室温保存,至少6个月有效。如果溶于非DMSO溶剂,建议分装后-80℃保存,预计6个月内有效。