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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1102-10mM | 厚朴酚(98%, HPLC) | 10mM×0.2ml | 70.00元 |
| SM1102-25mg | 厚朴酚(98%, HPLC) | 25mg | 60.00元 |
| SM1102-100mg | 厚朴酚(98%, HPLC) | 100mg | 204.00元 |
| 中文名 | 厚朴酚 |
| 英文名 | Magnolo |
| 中文别名 | - |
| 英文别名 | 5,5'-Diallyl-2,2'-biphenyldiol |
| 来源 | 厚朴Magnolia officinalis Rehd. et Wils. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>木脂素>其他木脂素 |
| 化学式 | C18H18O2 |
| 分子量 | 266.33 |
| CAS号 | 528-43-8 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/ml (375.47 mM) |
| 溶液配制 | 5mg加入1.88ml DMSO，或者每2.66mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively. | ||||
| 信号通路 | - | ||||
| 靶点 | RXRα | PPARγ | - | - | - |
| IC50 | 10.4 µM | 17.7 µM | - | - | - |
| 体外研究 | Magnolol is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively. Magnolol (26.2-80 µM) binds to RXRαLBD and PPARγLBD in a dose dependent manner, with Kd values of 45.7 µM and 1.67 µM, respectively. Magnolol (1-20 µM) induces the transcription of PPRE in a dose-dependent manner, but shows no activity on RXRE transcription1. Magnolol (1, 3, 10 µM) enhances adipocyte differentiation of both 3T3-L1 pre-adipocystes and C3H10T1/2 pluripotent stem cells in the presence of insulin. Magnolol (10 μM) upregulates mRNA expression of marker genes for adipocyte differentiation. Magnolol (1, 10 μM) shows an increase in basal and insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes. | ||||
| 体内研究 | Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice. | ||||
| 临床实验 | N/A | ||||
1.Zhang H, et al. PLoS One. 2011,6(11):e28253.
2.Choi SS, et al. Life Sci. 2009,84(25-26):908-14.
3.Zhao L, et al. Molecules. 2017,22(7):1218.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1102-10mM | 厚朴酚(98%, HPLC) | 10mM×0.2ml |
| SM1102-25mg | 厚朴酚(98%, HPLC) | 25mg |
| SM1102-100mg | 厚朴酚(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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