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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1110-10mM | 木兰脂素(98%, HPLC) | 10mM×0.2ml | 141.00元 |
| SM1110-5mg | 木兰脂素(98%, HPLC) | 5mg | 173.00元 |
| SM1110-25mg | 木兰脂素(98%, HPLC) | 25mg | 720.00元 |
| SM1110-100mg | 木兰脂素(98%, HPLC) | 100mg | 2448.00元 |
化学信息：
| 中文名 | 木兰脂素 |
| 英文名 | Magnolin |
| 中文别名 | 望春花素；木兰苷 |
| 英文别名 | - |
| 来源 | 木兰Magnolia liliflora Desr |
| 化合物类型 | 苯丙素类(Phenylpropanoids)>木脂素>双环氧木脂素 |
| 化学式 | C23H28O7 |
| 分子量 | 416.46 |
| CAS号 | 31008-18-1 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/ml (240.12 mM) |
| 溶液配制 | 5mg加入1.20ml DMSO，或者每4.16mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively. | ||||
| 信号通路 | - | ||||
| 靶点 | ERK1 | ERK2 | IκBα | - | - |
| IC50 | 87 nM | 16.5 nM | - | - | - |
| 体外研究 | Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. Magnolin inhibits NF-κB transactivation activity by suppressing the ERKs/RSK2 signaling pathway. Magnolin inhibits the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) by inhibiting extracellular signal-regulated kinases (ERKs), which are key signaling molecules in the regulation of cell proliferation, transformation and cancer cell metastasis. JB6 Cl41 cell migration enhanced by EGF treatment is dramatically suppressed by Magnolin treatment in a dose-dependent manner. Magnolin inhibits ERK1/2/RSK2 signaling-mediated IκBα phosphorylation at Ser32, resulting in the inhibition of NF-κB activation and cell migration. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1. Lee CJ, et al. BMC Cancer. 2015,15:576.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1110-10mM | 木兰脂素(98%, HPLC) | 10mM×0.2ml |
| SM1110-5mg | 木兰脂素(98%, HPLC) | 5mg |
| SM1110-25mg | 木兰脂素(98%, HPLC) | 25mg |
| SM1110-100mg | 木兰脂素(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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