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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM4184-10mM | 巴豆苷(98%, HPLC) | 10mM×0.2ml | 128.00元 |
| SM4184-5mg | 巴豆苷(98%, HPLC) | 5mg | 211.00元 |
| SM4184-25mg | 巴豆苷(98%, HPLC) | 25mg | 880.00元 |
化学信息：
| 中文名 | 巴豆苷 |
| 英文名 | Crotonoside |
| 中文别名 | 异鸟苷;2-羟基腺苷 |
| 英文别名 | Isoguanosine；2-Hydroxyadenosine |
| 来源 | 巴豆Croton tiglium L. |
| 化合物类型 | 生物碱(Alkaloids)>组氨酸系生物碱(Alkaloids) |
| 化学式 | C10H13N5O5 |
| 分子量 | 283.24 |
| CAS号 | 1818-71-9 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 25 mg/ml (88.26 mM) |
| 溶液配制 | 5mg加入1.77ml DMSO，或者每2.83mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML. | ||||
| 信号通路 | - | ||||
| 靶点 | Akt/mTOR | STAT5 | FLT3 | HDAC3 | HDAC6 |
| IC50 | 12.5 μM | 12.5 μM | - | - | - |
| 体外研究 | Crotonoside (0-200 μM;) selectively inhibits the viability of AML cell line MV4-11, MOLM-13 (with FLT3-ITD mutant) and KG-1 (without FLT3-ITD mutant) in a dose-dependent manner with an IC50 of 11.6 μM, 12.7 μM and 17.2 μM, respectively. Crotonoside (0-100μM; 7 hours) inhibits the phosphorylation of FLT3 Erk1/2, Akt/mTOR and STAT5 is strongly inhibited by crotonoside at higher concentration of 12.5 μM in a concentration-dependent manner. Crotonoside (0-100 μM; 12 hours) exhibits a dose-dependent increase in the percentage of G0/G1 phase and a dose-dependent decrease in the percentage of G2/M and S phases cells. Crotonoside (0-100 μM; 24 hours) leads to concentration-dependent changes in the number of apoptotic MV4-11 cells, results in a dose-dependent decrease in the level of pro-caspase-3 and a dose-dependent increase in the level of the cleaved caspase-3 fragments. | ||||
| 体内研究 | Crotonoside(intraperitoneal and intravenous injection; 70 mg/kg, 35 mg/kg; once daily) induces a significant antitumor activity and inhibited xenograft tumor progress as compared to treatment with vehicle. | ||||
| 临床实验 | N/A | ||||
1. Li YZ,et al. Oncotarget, 2017,8(61):103087-103099.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM4184-10mM | 巴豆苷(98%, HPLC) | 10mM×0.2ml |
| SM4184-5mg | 巴豆苷(98%, HPLC) | 5mg |
| SM4184-25mg | 巴豆苷(98%, HPLC) | 25mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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