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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM6136-10mM | 积雪草苷(98%, HPLC) | 10mM×0.2ml | 123.00元 |
| SM6136-5mg | 积雪草苷(98%, HPLC) | 5mg | 58.00元 |
| SM6136-25mg | 积雪草苷(98%, HPLC) | 25mg | 240.00元 |
| SM6136-100mg | 积雪草苷(98%, HPLC) | 100mg | 816.00元 |
化学信息：
| 中文名 | 积雪草苷 |
| 英文名 | Asiaticoside |
| 中文别名 | - |
| 英文别名 | - |
| 来源 | 积雪草Centella asiatica (L.) Urban |
| 化合物类型 | 萜类(Terpenoids)>三萜>乌苏烷型五环三萜皂苷 |
| 化学式 | C48H78O19 |
| 分子量 | 959.12 |
| CAS号 | 16830-15-2 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO : 50 mg/ml (52.13 mM) |
| 溶液配制 | 10mg加入1.04ml DMSO，或者每9.59mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties. | ||||
| 信号通路 | Stem Cell/Wnt; TGF-beta/Smad | ||||
| 靶点 | NF-κB | p38 | MAPK | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | Asiaticoside (0, 100, 250, and 500 mg/L) dose-dependently inhibits keloid fibroblasts proliferation. Asiaticoside (100, 250, and 500 mg/L) decreases the expression of collagen protein and mRNA, reduces the expression of TGF-bRI, TGF-bRII protein, and mRNA, increases the expression of Smad7, but does not affect Smad2, Smad3, Smad4, phosphorylated Smad2, and phosphorylated Smad3 in keloid fibroblasts. Asiaticoside (12.5 and 50, and 25 and 50 µg/ml) prevents endothelial cells from hypoxia-induced inhibition of cell viability and NO production. Asiaticoside (50 µg/ml) also protects endothelial cells from hypoxia-induced apoptosis and upregulates and phosphorylation of AKT/eNOS in hypoxia-exposed HPAECs. | ||||
| 体内研究 | Asiaticoside (50 mg/kg daily) blocks the development of hypoxic pulmonary hypertension (PH), cardiovascular remodeling and endothelial cell injury in rats with pulmonary hypertension. Asiaticoside (5, 15 or 45 mg/kg, p.o.) improves the learning and memory deficit, protects hippocampi against the impairment, decreases Aβ deposits in the hippocampus, and ameliorates impaired subcellular structure in rats treated with Aβ oligomers. | ||||
| 临床实验 | N/A | ||||
1. Tang B, et al. Arch Dermatol Res. 2011,303(8):563-72.
2. Wang X, et al. Mol Med Rep. 2018,17(2):2893-2900.
3. Zhang Z, et al. Exp Ther Med. 2017,13(2):413-420.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM6136-10mM | 积雪草苷(98%, HPLC) | 10mM×0.2ml |
| SM6136-5mg | 积雪草苷(98%, HPLC) | 5mg |
| SM6136-25mg | 积雪草苷(98%, HPLC) | 25mg |
| SM6136-100mg | 积雪草苷(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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