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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM7020-10mM | 薯蓣皂苷(98%, HPLC) | 10mM×0.2ml | 120.00元 |
| SM7020-5mg | 薯蓣皂苷(98%, HPLC) | 5mg | 60.00元 |
| SM7020-25mg | 薯蓣皂苷(98%, HPLC) | 25mg | 250.00元 |
| SM7020-100mg | 薯蓣皂苷(98%, HPLC) | 100mg | 850.00元 |
化学信息：
| 中文名 | 薯蓣皂苷 |
| 英文名 | Dioscin |
| 中文别名 | 薯蓣皂甙 |
| 英文别名 | Collettinside III |
| 来源 | 穿龙薯蓣Discorea nipponica Makino |
| 化合物类型 | 甾体类(Steroids)>甾体皂苷 |
| 化学式 | C45H72O16 |
| 分子量 | 869.04 |
| CAS号 | 19057-60-4 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | Water: < 0.1 mg/ml (insoluble); DMSO: ≥ 100 mg/ml (115.07 mM) |
| 溶液配制 | 10mg加入1.15ml DMSO，或者每8.69mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | Dioscin(CCRIS 4123; Collettiside III) is a natural steroid saponin derived from several plants, showing potent anti-cancer effect against a variety of tumor cell lines. | ||||
| 信号通路 | Apoptosis | ||||
| 靶点 | AKT | NF-κB | NFATc1 | - | - |
| IC50 | 1, 2 and 4 μM | 1, 2 and 4 μM | 1, 2 and 4 μM | - | - |
| 体外研究 | Anticancer agent in vitro: dioscin (1, 2 and 4 μmol/L) could significantly inhibit the viability of LNCaP cells in a time- and concentration-dependent manner. Flow cytometry revealed that the apoptosis rate was increased after treatment of LNCaP cells with dioscin for 24 h, indicating that apoptosis was an important mechanism by which dioscin inhibited cancer 1. dioscin abrogated AKT phosphorylation, which subsequently impaired RANKL-induced nuclear factor-kappaB (NF-κB) signaling pathway and inhibited NFATc1 transcriptional activity. | ||||
| 体内研究 | Moreover, in vivo studies further verified the bone protection activity of dioscin in osteolytic animal model Dioscin reduced cell death and lactate dehydrogenase (LDH) release in cells subjected to I/R. I/R induced apoptosis and cytochrome c release from mitochondria to the cytosol and this was prevented by dioscin. In support, dioscin decreased Bax but increased Bcl-2 mRNA expression. Dioscin prevented I/R induced dissipation of ΔΨm. | ||||
| 临床实验 | N/A | ||||
1. Chen J, et al. J Huazhong Univ Sci Technolog Med Sci. 2014,34(1):125-30.
2. Qu X, et al. Biochem Biophys Res Commun. 2014,443(2):658-65.
3. Qin J, et al. Drug Res (Stuttg). 2014,64(1):47-52.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM7020-10mM | 薯蓣皂苷(98%, HPLC) | 10mM×0.2ml |
| SM7020-5mg | 薯蓣皂苷(98%, HPLC) | 5mg |
| SM7020-25mg | 薯蓣皂苷(98%, HPLC) | 25mg |
| SM7020-100mg | 薯蓣皂苷(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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