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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM8008-5mg | 6-姜辣素(98%, HPLC) | 5mg | 144.00元 |
| SM8008-25mg | 6-姜辣素(98%, HPLC) | 25mg | 600.00元 |
| SM8008-100mg | 6-姜辣素(98%, HPLC) | 100mg | 2040.00元 |
化学信息：
| 中文名 | 6-姜辣素 |
| 英文名 | 6-Gingerol |
| 中文别名 | 6-姜酚 |
| 英文别名 | - |
| 来源 | 姜Zingiber officinale Rosc. |
| 化合物类型 | 酚类(Phenols) |
| 化学式 | C17H26O4 |
| 分子量 | 294.39 |
| CAS号 | 23513-14-6 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 50 mg/ml (169.84 mM) |
| 溶液配制 | 5mg加入1.70ml DMSO，或者每2.94mg加入1ml DMSO，配制成10mM溶液。 |
生物信息
| 产品描述 | 6-Gingerol is an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. | ||||
| 信号通路 | Apoptosis; AMPK | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | 6-gingerol inhibits colon cancer cell proliferation and induced apoptosis, while the normal colon cells are unaffected. 6-gingerol down-regulates phorbol myristate acetate induced phosphorylation of ERK1/2 and JNK MAP kinases and activation of AP-1 transcription factor, but has only little effects on phosphorylation of p38 MAP kinase and activation of NF-kappa B. 6-gingerol treatment is shown to restore impaired intestinal barrier function and to suppress proinflammatory responses in DSS-treated Caco-2 monolayers. AMPK is activated on 6-gingerol treatment. Treatment with 6-gingerol results in a significant decrease in the viability of osteosarcoma cells in a dose-dependent fashion. In parallel, the number of cells arrested at the sub-G1 cell cycle phase is significantly increased. 6-gingerol induces activation of caspase cascades and regulates cellular levels of Bcl2 and Bax. | ||||
| 体内研究 | In animal studies, 6-gingerol significantly ameliorates DSS-induced colitis by restoration of body weight loss, reduction in intestinal bleeding, and prevention of colon length shortening. In addition, 6-gingerol suppresses DSS-elevated production of proinflammatory cytokines (IL-1β, TNFα, and IL-12). | ||||
| 临床实验 | N/A | ||||
1. Radhakrishnan EK, et al. PLoS One. 2014,9(8):e104401.
2. Chang KW, et al. Food Funct. 2015,6(10):3334-41.
3. Fan J, et al. Tumour Biol. 2015,36(2):1135-41.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM8008-5mg | 6-姜辣素(98%, HPLC) | 5mg |
| SM8008-25mg | 6-姜辣素(98%, HPLC) | 25mg |
| SM8008-100mg | 6-姜辣素(98%, HPLC) | 100mg |
| - | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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