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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| P9085-5mg | Semaglutide (司美格鲁肽, BioReagent) | 5mg | 298.00元 |
| P9085-25mg | Semaglutide (司美格鲁肽, BioReagent) | 25mg | 698.00元 |
| P9085-100mg | Semaglutide (司美格鲁肽, BioReagent) | 100mg | 1398.00元 |
| CAS Number | Chemical Formula | Molecular Weight | Purity | Grade |
| 910463-68-2 | C187H291N45O59 | ~4113.6 | ≥98.0% | BioReagent |
基本信息(General Information)：
| Name (Chinese) | 司美格鲁肽 |
| Name (English) | Semaglutide |
| Specifications | BioReagent |
| Chemical Formula | C187H291N45O59 |
| Synonym (Chinese) | 索马鲁肽；索玛鲁肽；司马鲁肽 |
| Synonym (English) | Sermaglutide; Ozempic; Rybelsus; Wegovy; GLP-1R Agonist; NN 9535; NN-9535 |
| Sequence (Three-Letter Code) |
His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-AEEA-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH |
| Sequence (One-Letter Code) |
H-{Aib}-EGTFTSDVSSYLEGQAA-{C18 diacid-γ-Glu-(AEEA)2-Lys}-EFIAWLVRGRG |
| Source | Synthetic |
| Reconstitution | Ultrapure water: ＞10mg/ml or refer to the relevant literatures |
产品描述(Description)：
| Application | Semaglutide is a polypeptide that contains a linear sequence of 31 amino acids joined together by peptide linkages. It is an agonist of glucagon-like peptide-1 receptors (GLP-1 AR) and used for the treatment of type 2 diabetes. It has a role as a hypoglycemic agent, a glucagon-like peptide-1 receptor agonist, an anti-obesity agent, a neuroprotective agent and an appetite depressant. It is a polypeptide and a lipopeptide. |
| General Description | Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib8, Arg34) and is derivatized at lysine 26. The GLP-1R affinity of Semaglutide is 0.38±0.06nM. Semaglutide is a GLP-1 analogue with 94% sequence homology to human GLP-1 [1-2]. On September 20, 2019, Novo Nordisk announced that the U.S. Food and Drug Administration (FDA) had approved Rybelsus® (semaglutide) tablets 7 mg or 14 mg for adults with type 2 diabetes that along with diet and exercise may improve blood sugar (glucose). Rybelsus® is the first and only glucagon-like peptide-1 (GLP-1) analog in a pill and a new option for adults with type 2 diabetes who are not achieving their A1C goal with current antidiabetic treatment. |
性质(Properties)：
| Form | White powder |
| Solubility | Freely soluble in water |
安全信息(Safety Information)：
| Hazard Pictogram Codes |  |
| Signal Word | Warning |
| Hazard Statements | H361-H361d |
| Precautionary Statements | P203-P280-P318-P405-P501 |
| Personal Protective Equipment | - |
| Hazard Codes (Europe) | - |
| Risk Codes (Europe) | - |
| Safety Codes (Europe) | - |
| RIDADR | - |
| WGK Germany | - |
| RTECS | - |
| Flash Point (F) | - |
| Flash Point (C) | - |
| 产品编号 | 产品名称 | 包装 |
| P9085-5mg | Semaglutide (BioReagent) | 5mg |
| P9085-25mg | Semaglutide (BioReagent) | 25mg |
| P9085-100mg | Semaglutide (BioReagent) | 100mg |
| － | 说明书 | 1份 |
-20ºC避光保存，一年有效。
注意事项：本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
参考文献：1.Dhillon S. Semaglutide: First Global Approval. Drugs. 2018. 78(2):275-284.
2.Marso SP, Bain SC, Consoli A, Eliaschewitz FG, et al. N Engl J Med. 2016. 375(19):1834-1844.
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| P9087 | Semaglutide Intermediate P29 (司美格鲁肽中间体P29) | 5/25/100mg |
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