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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1142-10mM | 东莨菪内酯(98%, HPLC) | 10mM×0.2ml | 74.00元 |
| SM1142-25mg | 东莨菪内酯(98%, HPLC) | 25mg | 175.00元 |
| SM1142-100mg | 东莨菪内酯(98%, HPLC) | 100mg | 595.00元 |
| 中文名 | 东莨菪内酯 |
| 英文名 | Scopoletin |
| 中文别名 | 莨菪亭；东莨菪亭 |
| 英文别名 | Chysatroic acid；Escoopoletin；Gelseminic acid；Scopoletol；6-Methoxy-7-hydroxycoumarin |
| 来源 | 丁公藤Erycibe obtusifolia Benth.；白花蛇舌草Hedyotis diffusa Willd；东莨菪Scopolia japonica Maxin.； |
| 化合物类型 | 苯丙素类(Phenylpropanoids)＞香豆素类(Coumarins) |
| 化学式 | C10H8O4 |
| 分子量 | 192.17 |
| CAS号 | 92-61-5 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 32 mg/mL (166.52 mM) |
| 溶液配制 | 2mg加入1.04mL DMSO，或者每1.92mg加入1mL DMSO，配制成10mM溶液。 |
| 产品描述 | Scopoletin is an inhibitor of acetylcholinesterase (AChE). | ||||
| 信号通路 | Apoptosis | ||||
| 靶点 | AChE | - | - | - | - |
| IC50 | 4 μM | - | - | - | - |
| 体外研究 | Scopoletin (SCT) is identified as a putative inhibitor of acetylcholinesterase (AChE). Scopoletin enhances the K+-stimulated release of ACh from rat frontal cortex synaptosomes, showing a bell-shaped dose effect curve (Emax: 4 μM). Scopoletin inhibits PC3 proliferation by inducing apoptosis of PC3 cells. The IC50 of Scopoletin for inhibiting PC3, PAA (human lung cancer cell), and Hela cell proliferation is (157±25), (154±51), and (294±100) mg/L, respectively. Scopoletin induces a marked time- and concentration-dependent inhibition of PC3 cell proliferation. Scopoletin reduces the protein content and decreases the acid phosphatase activity (ACP) level in PC3 cells in a concentration-dependent manner. Cells treated by Scopoletin show typical morphologic changes of apoptosis by light microscope, fluorescence microscope, and transmission electronmicroscope. Apoptosis rate is 0.3 %, 2.1 %, 9.3 % and 35 % for Scopoletin 0, 100, 200, and 400 mg/L, respectively, and cells in G2 phase decrease markedly after being treated with Scopoletin. | ||||
| 体内研究 | Scopoletin (2 μg, i.c.v.) increases T-maze alternation and ameliorated novel object recognition of mice with scopolamine-induced cholinergic deficit. It also reduces age-associated deficits in object memory of 15-18-month-old mice (2 mg/kg sc). Mice injected with 2 μg Scopoletin show an increased alternation rate of 71.3±2.5%. | ||||
| 临床实验 | N/A | ||||
1.Hornick A, et al. Neuroscience. 2011,197:280-92.
2.Liu XL, et al. Acta Pharmacol Sin. 2001,22(10):929-33.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1142-10mM | 东莨菪内酯(98%, HPLC) | 10mM×0.2ml |
| SM1142-25mg | 东莨菪内酯(98%, HPLC) | 25mg |
| SM1142-100mg | 东莨菪内酯(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
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