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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM1152-10mM | 异补骨脂素(98%, HPLC) | 10mM×0.2ml | 72.00元 |
| SM1152-25mg | 异补骨脂素(98%, HPLC) | 25mg | 132.00元 |
| SM1152-100mg | 异补骨脂素(98%, HPLC) | 100mg | 448.00元 |
| 中文名 | 异补骨脂素 |
| 英文名 | Angelicin |
| 中文别名 | 当归素；异香柠檬烯；异佛手柑内酯；异补骨酯素 |
| 英文别名 | Isopsoralen; Bakuchicin |
| 来源 | 补骨脂Psoralea corylifolia Linn. |
| 化合物类型 | 苯丙素类(Phenylpropanoids)＞香豆素类(Coumarins)>角型呋喃香豆素 |
| 化学式 | C11H6O3 |
| 分子量 | 186.16 |
| CAS号 | 523-50-2 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 |
Water: < 0.1 mg/ml (insoluble); DMSO: 33.33 mg/ml (179.04 mM) |
| 溶液配制 | 2mg加入1.07ml DMSO，或者每1.86mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity. | ||||
| 信号通路 | Apoptosis | ||||
| 靶点 | - | - | - | - | - |
| IC50 | - | - | - | - | - |
| 体外研究 | In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells. Angelicin was potentially advantageous to prevent inflammatory diseases by inhibiting NF-κB and MAPK pathways. | ||||
| 体内研究 | N/A | ||||
| 临床实验 | N/A | ||||
1.Md. Ataur Rahman, et al. Molecular and Cellular Biochemistry. 2012,369(1-2):95-104.
2.Hye-Jeong Cho, et al. Antiviral Research. 2013,100(1):75-83.
3.Fang Liu, et al. Journal of Surgical Research. 2013,185(1):300-309.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM1152-10mM | 异补骨脂素(98%, HPLC) | 10mM×0.2ml |
| SM1152-25mg | 异补骨脂素(98%, HPLC) | 25mg |
| SM1152-100mg | 异补骨脂素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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