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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM5060-10mM | (+)-冰片(98%, HPLC) | 10mM×0.2ml | 68.00元 |
| SM5060-25mg | (+)-冰片(98%, HPLC) | 25mg | 60.00元 |
| SM5060-100mg | (+)-冰片(98%, HPLC) | 100mg | 204.00元 |
| 中文名 | (+)-冰片 |
| 英文名 | (+)-Borneol |
| 中文别名 | D-龙脑 |
| 英文别名 | (1R,2S,4R)-Borneol; endo-(1R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol；d-Borneol |
| 来源 | 艾纳香Blumea balsamifera（L.) DC.；香樟Cinnamomum camphora (Linn) Presl |
| 化合物类型 | 萜类(Terpenoids)>单萜 |
| 化学式 | C10H18O |
| 分子量 | 154.25 |
| CAS号 | 464-43-7 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/mL (648.30 mM) |
| 溶液配制 | 2mg加入1.30ml DMSO，或者每1.54mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | (+)-BORNEOL is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine. (+)-BORNEOL enhances GABA receptor activity with an EC50 of 248 μM. | ||||
| 信号通路 | - | ||||
| 靶点 | GABA | - | - | - | - |
| IC50 | 248 μM | - | - | - | - |
| 体外研究 | (+)-borneol significantly inhibits the expression of iNOS and TNF-α in a dose-dependent manner in the LPS-stimulated BV-2 cells[1]. Aβ-induced cell cytotoxicity is inhibited by 100μM of (-) and (+) borneol treatment. Treatment of borneol significantly decreases ROS generation. The expression of HO-1 and nuclear translocation of Nrf2 are increased by Aβ treatment. This nuclear translocation of Nrf2 is further increased by administration of borneol. Compared with the Aβ treated group, the (+) borneol treated group significantly increases Bcl-2 expression with decreased expression of Bax. Thus, Borneol protects SH-SY5Y cells against Aβ-induced toxicity, exerts an antioxidative effect and suppresses apoptosis | ||||
| 体内研究 | (+)-borneol (1.0 mg/kg) significantly ameliorated infarct size and neurological scoresvia reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in a dose dependent manner. Notably, (+)-borneol showed long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreased the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. Suggest that (+)-borneol could serve as a therapeutic target for ischemic stroke. | ||||
| 临床实验 | N/A | ||||
1.Hur J, et al. Pharmaceutical Biology. 2013,51(1):30-35.
2.Chang L, et al. Journal of Biomedical Research. 2017,31(4):306-314.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM5060-10mM | (+)-冰片(98%, HPLC) | 10mM×0.2ml |
| SM5060-25mg | (+)-冰片(98%, HPLC) | 25mg |
| SM5060-100mg | (+)-冰片(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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